Opportunity Information: Apply for 23 516

The NSF Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II opportunity (Funding Opportunity Number 23-516) is a National Science Foundation grant program designed to help US startups and small businesses advance promising technologies beyond the earliest proof-of-concept stage and move them closer to real-world deployment and commercialization. The program traces its roots back to an NSF pilot launched in 1977 to support high-risk, potentially high-payoff innovation in small firms, and it continues that same core purpose today: using targeted federal support to turn strong science and engineering ideas into products, services, and scalable solutions that can generate broad societal and economic benefits.

At its core, this Phase II program focuses on translation rather than basic research. NSF is not primarily funding open-ended discovery science here; instead, it is backing the kind of research and development work that helps a company take a breakthrough grounded in science or engineering and push it out of the lab and toward the market or other large-scale use. A defining feature is that it provides non-dilutive funding, meaning the company can pursue technical development without giving up equity, which is especially important at early stages when private capital may be expensive or hard to obtain due to technical and market risk.

The solicitation emphasizes that proposals should be rooted in groundbreaking scientific discoveries or significant engineering breakthroughs aligned with NSF's broader mission to advance science, strengthen national health and prosperity, and support national welfare and defense. The program operates under the federal SBIR/STTR statute (15 U.S.C. 638) and the National Science Foundation Act of 1950 (as amended), which frame how NSF supports small businesses in developing innovative technologies that have commercial potential or clear societal value.

A notable aspect of the NSF SBIR/STTR program is its broad topic openness. Unlike many funding opportunities that narrow applicants into a short list of priority areas, NSF explicitly states that it does not have a single technological focus and welcomes proposals across many technical and market domains. NSF maintains a topic portfolio and points applicants to its Seed Fund website for examples and program staff contacts. If a proposed technology does not neatly fit an existing topic area, the program allows submission under an "Other Topics" category, signaling a willingness to consider novel or emerging areas that may not yet be formally categorized.

From a policy and impact standpoint, the program aims to strengthen the national economy by stimulating private-sector innovation, expanding the role of small businesses in meeting federal research and development needs, and increasing the commercial application of research results that were supported by federal investment. It also highlights workforce development as an intended outcome, with a particular emphasis on fostering participation among socially and economically disadvantaged and women-owned small businesses, reflecting NSF's interest in broadening innovation and entrepreneurship opportunities across the US.

Administratively, the opportunity is a discretionary grant in the science and technology research and development category, offered by the National Science Foundation. It lists multiple CFDA numbers (47.041, 47.049, 47.050, 47.070, 47.074, 47.075, 47.076, 47.079, 47.083, 47.084), reflecting NSF's coverage across a wide range of research domains. The posted record indicates an expected 110 awards, with an award ceiling shown as 0 in the extracted listing (which typically means the ceiling is not specified in that particular field rather than implying no funding). The original closing date shown is March 1, 2023, and eligibility is broadly described as "Others" with additional eligibility details referenced in the full announcement text.

In practical terms, this Phase II opportunity is best understood as NSF's mechanism for helping small businesses bridge the gap between early technical feasibility and a solution that is credible to customers, partners, and follow-on funders. It is aimed at companies that can articulate both a strong technical innovation case and a clear path to impact, whether that impact is commercial adoption, large-scale deployment, or measurable societal benefit.

  • The National Science Foundation in the science and technology and other research and development sector is offering a public funding opportunity titled "NSF Small Business Innovation Research / Small Business Technology Transfer Programs Phase II" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 47.041, 47.049, 47.050, 47.070, 47.074, 47.075, 47.076, 47.079, 47.083, 47.084.
  • This funding opportunity was created on Nov 18, 2022.
  • Applicants must submit their applications by Mar 01, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 110 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for 23 516

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Small Business Innovation Research/ Small Business Technology Transfer Program Phase I Apply for 23 515

Funding Number: 23 515
Agency: National Science Foundation
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Funding Amount: Case Dependent
Advanced Computing Systems & Services: Adapting to the Rapid Evolution of Science and Engineering Research Apply for 23 518

Funding Number: 23 518
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
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DEVCOM ARMY RESEARCH LABORATORY BROAD AGENCY ANNOUNCEMENT FOR FOUNDATIONAL RESEARCH Apply for W911NF 23 S 0001

Funding Number: W911NF 23 S 0001
Agency: Department of Defense, Dept of the Army -- Materiel Command
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
Fiscal Year (FY) 2023 Create the Future Independent Research Effort Apply for FOA AFRL AFOSR 2023 0001

Funding Number: FOA AFRL AFOSR 2023 0001
Agency: Department of Defense, Air Force Office of Scientific Research
Category: Science and Technology and other Research and Development
Funding Amount: $4,500,000
Campus Cyberinfrastructure Apply for 23 526

Funding Number: 23 526
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: $1,200,000
NSF/CASIS Collaboration on Tissue Engineering and Mechanobiology on the International Space Station (ISS) to Benefit Life on Earth Apply for 23 522

Funding Number: 23 522
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
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Oceanographic Facilities and Equipment Support Apply for 23 525

Funding Number: 23 525
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: $47,500,000
2023 HERO Appendix A: NASA Human Research Program Omnibus Opportunity Apply for NNJ23ZSA001N OMNIBUS

Funding Number: NNJ23ZSA001N OMNIBUS
Agency: National Aeronautics and Space Administration, NASA Johnson Space Center
Category: Science and Technology and other Research and Development
Funding Amount: $150,000
NSF Scholarships in Science, Technology, Engineering, and Mathematics Program Apply for 23 527

Funding Number: 23 527
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: $5,000,000
Switzer Research Fellowships Program Apply for HHS 2023 ACL NIDILRR SFGE 0000

Funding Number: HHS 2023 ACL NIDILRR SFGE 0000
Agency: Department of Health and Human Services, Administration for Community Living
Category: Science and Technology and other Research and Development
Funding Amount: $80,000
DOD Reconstructive Transplant Clinical Network Award Apply for HT9425 23 RTRP CNA

Funding Number: HT9425 23 RTRP CNA
Agency: Department of Defense, Dept. of the Army -- USAMRAA
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
Defense Production Act Title III Expansion of Domestic Production Capability and Capacity; CALL 012 - Critical Chemicals Production Apply for FA8650 19 S 5010 CALL 012

Funding Number: FA8650 19 S 5010 CALL 012
Agency: Department of Defense, Air Force -- Research Lab
Category: Science and Technology and other Research and Development
Funding Amount: $200,000,000
FY 2023 Phase I Release 2 Apply for DE FOA 0002903

Funding Number: DE FOA 0002903
Agency: Department of Energy - Office of Science, Office of Science
Category: Science and Technology and other Research and Development
Funding Amount: $250,000
Research Coordination Networks (RCN) Apply for 23 529

Funding Number: 23 529
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
Archaeology Program - Doctoral Dissertation Research Improvement Grants Apply for 23 531

Funding Number: 23 531
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: $25,000
Geosciences Open Science Ecosystem Apply for 23 534

Funding Number: 23 534
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: $1,600,000
Design for Environmental Sustainability in Computing Apply for 23 532

Funding Number: 23 532
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
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Nonproliferation & Arms Control Program Studies, Training & Outreach Apply for DE FOA 0002899

Funding Number: DE FOA 0002899
Agency: Department of Energy, NNSA
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Emerging Mathematics in Biology Apply for 23 537

Funding Number: 23 537
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: Case Dependent
Scholarships in STEM Network Apply for 23 536

Funding Number: 23 536
Agency: National Science Foundation
Category: Science and Technology and other Research and Development
Funding Amount: $15,000,000

 

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