Opportunity Information: Apply for W81XWH 18 LRP CA
The DoD Lupus, Concept Award (FY18 Lupus Research Program; opportunity number W81XWH-18-LRP-CA) is a Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) to back early-stage, high-risk, high-reward lupus research. The purpose of this mechanism is to let investigators test truly new ideas or unproven theories that address important problems in lupus, with the expectation that successful projects could open up entirely new directions for the field rather than extend what is already known in small steps. Projects funded through this award are meant to generate new insights and, if results are promising, can provide the kind of initial findings that help a Principal Investigator compete for larger follow-on research funding later.
A key theme of this award is that innovation is the top priority and the most important review criterion. Applications need to make a clear, explicit case that the proposed work is genuinely novel, such as introducing a new paradigm, reframing a longstanding challenge from a different angle, or applying a creative approach that changes how lupus is studied. Proposals that mainly represent an incremental continuation of the applicant’s existing research program, or that only slightly advance previously published work, are specifically discouraged and would not be viewed as meeting the intent of the Concept Award. Importantly, preliminary data is not required, which is meant to lower the barrier for pursuing bold concepts that have not yet been tested.
Beyond innovation, reviewers will also weigh the likely impact of the research on lupus. Applicants are expected to explain why the question matters, what gap it addresses, and how the findings could significantly affect understanding of lupus disease, its mechanisms, or future approaches to diagnosis, prevention, or treatment research. The research strategy is also a major component: the application should show strong scientific rationale and thoughtful experimental design that reflects deep familiarity with lupus biology and the current literature. While methods can be novel, they still need to be well-justified and credible, with a clear line of reasoning for how the work will test the central concept.
The proposed project must align with at least one of the FY18 Lupus Research Program Focus Areas, meaning applicants need to map their idea to the program’s stated priorities for that fiscal year. The announcement also makes clear that clinical trials are not allowed under this program, so projects must remain in the preclinical, mechanistic, translational (non-trial), or other non-clinical-trial research space consistent with the solicitation rules.
Funding is relatively modest by design, reflecting the exploratory nature of the award. The anticipated maximum total cost for the full period of performance is capped at $150,000. While the listing shows an award ceiling of $0 in the summary fields, the narrative section specifies the practical budget limit as not exceeding $150,000 total costs, with additional details governed by the program’s funding restrictions section. The program anticipated making about 12 awards.
Eligibility is described as unrestricted (open to any type of entity, subject to any additional eligibility clarifications in the full announcement). The opportunity was listed as discretionary, and funding could be made via a grant or cooperative agreement. Finally, all proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the broader American public, so applicants should connect the significance of their lupus concept to these populations and the DoD’s health-related mission.Apply for W81XWH 18 LRP CA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Lupus, Concept Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Jun 08, 2018.
- Applicants must submit their applications by Nov 07, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Lupus Concept Award (FY18 Lupus Research Program; W81XWH-18-LRP-CA)
What is the DoD Lupus Concept Award?
The DoD Lupus, Concept Award (FY18 Lupus Research Program; opportunity number W81XWH-18-LRP-CA) is a Department of Defense funding opportunity administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is intended to support early-stage, high-risk, high-reward lupus research that tests truly new ideas or unproven theories.
What is the main purpose of this award mechanism?
The mechanism is designed to let investigators explore bold, innovative concepts that address important problems in lupus. The goal is to generate new insights that could open entirely new directions for the field, rather than extend existing knowledge in small incremental steps.
What type of research is this opportunity meant to support?
This opportunity supports early-stage, exploratory lupus research where innovation is the central theme. Funded projects are expected to produce initial findings that, if promising, can position the Principal Investigator (PI) to pursue larger follow-on funding later.
What is the most important review criterion for applications?
Innovation is the top priority and the most important review criterion. Applications must make a clear and explicit case that the proposed work is genuinely novel.
How can an applicant demonstrate that a project is truly innovative?
Based on the announcement description, innovation can be demonstrated by proposing a new paradigm, reframing a longstanding challenge from a different angle, or applying a creative approach that changes how lupus is studied. The application should clearly explain what makes the idea new and why it is not simply an extension of existing work.
Are incremental projects encouraged or discouraged?
They are specifically discouraged. Proposals that mainly represent an incremental continuation of the applicant's existing research program, or that only slightly advance previously published work, are described as not meeting the intent of the Concept Award.
Is preliminary data required to apply?
No. Preliminary data is not required, which is intended to lower barriers for pursuing bold concepts that have not yet been tested.
Besides innovation, what else will reviewers consider?
Reviewers will also consider the likely impact of the research on lupus, including why the question matters, what gap it addresses, and how the findings could significantly affect understanding of lupus disease, its mechanisms, or future approaches to diagnosis, prevention, or treatment research. The research strategy, scientific rationale, and experimental design are also major components.
What should the research strategy emphasize?
The research strategy should present a strong scientific rationale and thoughtful experimental design that shows deep familiarity with lupus biology and the current literature. Even if methods are novel, they should be well-justified and credible, with a clear line of reasoning for how the work will test the central concept.
Does the proposed project need to align with specific program priorities?
Yes. The proposed project must align with at least one of the FY18 Lupus Research Program Focus Areas, and applicants are expected to map their idea to the program's stated priorities for that fiscal year.
Are clinical trials allowed under this funding opportunity?
No. The announcement states that clinical trials are not allowed under this program. Projects must remain in the preclinical, mechanistic, translational (non-trial), or other non-clinical-trial research space consistent with the solicitation rules.
What is the maximum funding amount for an award?
The anticipated maximum total cost for the full period of performance is capped at $150,000. Although the summary fields show an award ceiling of $0, the narrative specifies the practical budget limit as not exceeding $150,000 total costs (with additional details governed by the program's funding restrictions section).
Why does the listing show an award ceiling of $0 if funding is available?
The summary fields list an award ceiling of $0, but the narrative section provides the functional cap of up to $150,000 in total costs. In other words, the narrative section is where the meaningful budget limit is stated in the provided description.
How many awards does the program expect to make?
The program anticipated making about 12 awards.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is open to any type of entity, subject to any additional eligibility clarifications in the full announcement.
What kind of funding instrument will be used?
The opportunity is described as discretionary, and funding could be made via a grant or a cooperative agreement.
What populations must the proposed research be relevant to?
All proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the broader American public. Applicants should connect the significance of their lupus concept to these populations and to the DoD's health-related mission.
What is the overall intent of the award in terms of career or future funding?
The award is intended to help generate initial findings and new insights. If results are promising, they can provide the kind of early evidence that helps a PI compete for larger follow-on research funding later.
What is the administering organization for this opportunity?
The opportunity is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA) under the Department of Defense.
What is the opportunity number associated with this funding?
The opportunity number is W81XWH-18-LRP-CA.
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