Opportunity Information: Apply for PAR 24 260
The Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) opportunity (PAR-24-260) is a National Institutes of Health (NIH) discretionary grant mechanism that uses the R24 activity code and is designated as clinical trial not allowed. Its central aim is to strengthen Tribal research oversight by helping eligible Tribal entities either create a new Institutional Review Board (IRB) from the ground up or expand and professionalize the operations of an existing Tribal IRB. In practical terms, this funding is meant to build or deepen the infrastructure that supports ethical review of research involving human participants, with a specific focus on American Indian and Alaska Native (AI/AN) communities and the unique responsibilities and expectations that come with Tribal sovereignty, community priorities, and culturally grounded protections.
The program is targeted to federally recognized AI/AN Tribes, Tribal colleges and universities, Tribal health programs, and Tribal organizations, which NIH groups together as eligible Tribal entities. The eligible applicant list also notes Indian/Native American Tribal Governments that are not federally recognized as eligible in the listing provided. At the same time, the opportunity is clear about what is not allowed: non-U.S. (foreign) organizations cannot apply as applicants, and non-U.S. components of U.S. organizations are not eligible to apply. However, the notice does allow foreign components as NIH defines them in its Grants Policy Statement, meaning the project can include certain foreign elements under NIH rules even though foreign organizations themselves cannot be the applicant institution.
From a capacity-building standpoint, the award is designed to support the real-world needs of IRB establishment and enhancement. That generally includes developing governance structures, policies and standard operating procedures, reviewer recruitment and training, meeting and recordkeeping systems, compliance processes aligned with federal human subjects protections, and the administrative staffing and workflow needed to review research in a timely and consistent way. For Tribes or Tribal organizations that already have an IRB, the intent is to help scale up maturity and effectiveness, which can mean improving reviewer expertise, strengthening documentation and quality assurance, enhancing community engagement processes, adopting or improving electronic systems for protocol tracking, and creating sustainable operations that can handle more protocols or more complex reviews while still centering Tribal values and decision-making.
The sponsor is the National Institutes of Health, and the program sits within the health funding activity category under CFDA 93.859. The funding opportunity was created on August 12, 2024, and the original closing date listed is January 27, 2027, indicating a multi-year window in which NIH expects to receive applications across multiple receipt cycles depending on the notice. The listing as provided does not specify an award ceiling or an expected number of awards, so applicants typically need to consult the full announcement and NIH budget guidance to understand allowable costs, project period expectations, and how NIH anticipates sizing awards for different types of institutional starting points (new IRB establishment versus enhancement of an existing board).
Overall, TIRBEE is best understood as an investment in Tribal-led research governance. By funding the establishment or strengthening of Tribal IRBs, NIH is supporting the ability of Tribal communities and institutions to review, approve, require modifications to, or disapprove research affecting their citizens and communities, and to do so with locally defined ethical priorities, culturally informed safeguards, and stronger long-term research oversight capacity.Apply for PAR 24 260
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Tribal Institutional Review Board Establishment and Enhancement (TIRBEE) (R24 - Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
- This funding opportunity was created on 2024-08-12.
- Applicants must submit their applications by 2027-01-27.
- Eligible applicants include: Native American tribal governments (Federally recognized), Others.
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