Opportunity Information: Apply for CDC RFA GH 23 0045
The Centers for Disease Control and Prevention (CDC), within the Department of Health and Human Services (HHS), announced a discretionary funding opportunity titled "Regional Partnerships to Strengthen National Data Capacities for HIV, TB, and Other Pandemic Preparedness and Response under the President's Emergency Plan for AIDS Relief (PEPFAR)" (Funding Opportunity Number: CDC RFA GH 23 0045; CFDA: 93.067). The award is structured as a cooperative agreement, meaning recipients should expect substantial engagement from CDC in planning, implementation support, and technical collaboration rather than a hands-off grant relationship. The opportunity was posted on February 17, 2023, with an original application deadline of April 18, 2023 (applications due by 11:59 pm Eastern Time). Eligibility is listed as unrestricted, so a wide range of organizations may apply, subject to any additional eligibility clarifications in the full notice.
The program is designed to be implemented in PEPFAR-supported countries and centers on strengthening the data backbone that underpins effective responses to HIV, tuberculosis (TB), and other public health threats linked to pandemic preparedness and response. The core idea is to build and reinforce regional, national, and subnational institutions so they can independently design, operate, maintain, and continuously improve health data systems over time. In practice, this means the program is not only interested in producing analyses or running short-term data activities, but in developing lasting institutional capacity: governance, workforce skills, operational processes, and technical infrastructure that countries and regions can sustain financially and politically after external support decreases.
A key theme of the notice is balancing immediate implementation needs with long-term country ownership and sustainability. Many health programs face urgent data demands such as routine reporting, outbreak detection, program monitoring, and rapid assessments; at the same time, over-reliance on external partners can weaken local control and durability. This NOFO explicitly tries to keep those two pressures in equilibrium by supporting activities that deliver near-term improvements while also transferring expertise and authority to national and regional entities. Sustainability is framed broadly, including financial sustainability (ability to fund systems), operational sustainability (processes and staffing), technical sustainability (ability to maintain and upgrade tools), programmatic sustainability (embedding data use into decision-making), and political sustainability (institutional buy-in and ownership).
The technical scope spans the full data lifecycle and multiple complementary domains. Applicants are expected to support country-led or country-owned work in survey and surveillance systems (for example, strengthening routine surveillance, special studies, or sentinel approaches), monitoring and evaluation (often written as M&E), and advanced data management and analytics. The notice specifically calls out machine learning (ML) and artificial intelligence (AI) as part of the advanced analytics space, signaling interest in modern methods for data integration, prediction, anomaly detection, and decision support when appropriate and ethically implemented. In addition, the NOFO includes economic and cost analysis, which is crucial for understanding the cost-effectiveness of interventions, budgeting realistically for data systems, and informing national planning and resource allocation.
The expected activities range from capacity building and system strengthening to hands-on support for collecting, processing, analyzing, and using data. This can include developing workforce skills (training, mentorship, and institutional learning), improving data system architecture and interoperability, strengthening data quality and timeliness, creating or refining dashboards and reporting workflows, and supporting dissemination so that findings reach decision-makers and translate into action. The outcome CDC is emphasizing is a faster, higher-quality public health response, where reliable data flows quickly enough to guide HIV and TB programming and to strengthen readiness for other health threats, including emerging outbreaks.
In terms of funding, CDC anticipated approximately $63,000,000 in total fiscal year funding for Year 1, contingent on available funds, with an expectation of three awards. Notably, the notice lists an award ceiling for Year 1 as "$0 (none)," which generally indicates CDC did not set a maximum cap per award in the public-facing summary and instead may determine award sizes based on meritorious applications, proposed scope, country and regional coverage, and budget reasonableness. As a cooperative agreement, applicants would typically propose a detailed workplan and budget aligned to achieving measurable improvements in national and regional data capacity, while coordinating closely with CDC and in-country stakeholders to ensure alignment with PEPFAR priorities and national strategies.Apply for CDC RFA GH 23 0045
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Regional Partnerships to Strengthen National Data Capacities for HIV, TB, and Other Pandemic Preparedness and Response under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Feb 17, 2023.
- Applicants must submit their applications by Apr 18, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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