Practice-Based Research Integrating Multidisciplinary Experiences in Dental Schools (PRIMED) (U01 Clinical Trial Not Allowed) | RFA DE 23 012

Opportunity Information: Apply for RFA DE 23 012

The Practice-Based Research Integrating Multidisciplinary Experiences in Dental Schools (PRIMED) funding opportunity (RFA-DE-23-012) is a National Institutes of Health program administered by the National Institute of Dental and Craniofacial Research (NIDCR). It uses a cooperative agreement mechanism (U01), which means funded projects are expected to involve substantial scientific and programmatic involvement from NIH staff compared with a standard research grant. The overall purpose is to strengthen and expand practice-based research conducted directly in dental school predoctoral and postdoctoral clinics, while also building clinical research training and educational experiences into the day-to-day clinic environment. Importantly, this FOA is labeled "Clinical Trial Not Allowed," so applications must be structured to avoid proposing a clinical trial as defined by NIH.

The central idea behind PRIMED is that dental school clinics are unusually well suited for real-world, practice-based research. They combine general dentistry and multiple specialties under one roof, and they treat a diverse patient population with needs ranging from routine care to complex conditions. NIDCR is looking for research that takes advantage of that setting to generate practical, clinically meaningful evidence, while simultaneously giving students and trainees hands-on exposure to how clinical research is designed, implemented, and translated into patient care workflows. In other words, the research is not meant to sit apart from clinical training; it is meant to be integrated into it.

Applications are expected to address several core requirements. First, proposals must include genuine collaborative partnerships between research-focused faculty and clinically oriented faculty, reflecting an intentional bridge between the research mission and the realities of patient care in teaching clinics. Second, proposals must include intra- and/or inter-institutional collaborations, encouraging teams to work across departments, clinics, schools, or partner institutions to broaden expertise and increase the reach of the practice-based research environment. Third, projects must provide practice-based research experiences within the predoctoral/postdoctoral clinic setting by expanding or adapting clinic operations so that research activities can be embedded into clinical care and training. Fourth, they must include clinical research skills development, which can be delivered through coursework and/or other research education and training opportunities, so that learners and clinic personnel develop stronger competency in clinical research methods, implementation, and related professional skills.

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education institutions when specified in the category); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, tribal governments other than federally recognized, and U.S. territories or possessions. At the same time, it clearly restricts foreign involvement: non-U.S. entities (foreign organizations and foreign institutions) are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.

From an administrative standpoint, the opportunity falls under the health activity category and is associated with CFDA 93.121. The posting lists an original closing date of February 24, 2023, and a creation date of August 18, 2022. The award ceiling and expected number of awards are not specified in the provided listing, which typically means applicants need to consult the full FOA and related NIH guidance for budget expectations, project period limits, and the program’s anticipated funding level. Overall, PRIMED is designed for dental schools and their partners that want to deliberately blend clinic-based research, multidisciplinary collaboration, and structured clinical research training into the predoctoral and postdoctoral clinical environment, without proposing a clinical trial.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Practice-Based Research Integrating Multidisciplinary Experiences in Dental Schools (PRIMED) (U01 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121.
• This funding opportunity was created on 2022-08-18.
• Applicants must submit their applications by 2023-02-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA DE 23 012

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