Opportunity Information: Apply for RFA TS 21 001
The grant opportunity titled "Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS)" (Funding Opportunity Number RFA TS 21 001) is a discretionary federal grant sponsored by the Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), through the Agency for Toxic Substances and Disease Registry (ATSDR). Its central purpose is to fund investigator-initiated research that improves understanding of potential factors that may contribute to ALS and, in doing so, directly supports the broader mission of the National ALS Registry.
This funding call is closely tied to the National ALS Registry's core public health objectives. Those objectives include estimating ALS occurrence in two key ways: the number of new cases each year (incidence) and the number of people living with ALS at a given time (prevalence). Beyond counting cases, the Registry aims to deepen knowledge about who develops ALS by characterizing patterns across populations and to identify contributing factors that could influence ALS risk, including environmental contributors. In practical terms, the research ATSDR is seeking should help the Registry move from measuring the burden of ALS to better explaining why ALS occurs in certain groups and under certain exposures or life experiences.
ATSDR is specifically looking for studies that identify and evaluate risk factors associated with ALS, with a stated preference for several focus areas highlighted in the Notice of Funding Opportunity. These preferred topics include factors related to military service, participation in contact sports, traumatic brain injury, neuroinflammation, and infectious agents. The emphasis suggests a strong interest in projects that can clarify whether and how these exposures or biological pathways might be linked to ALS development, severity, or timing, and that can add credible evidence to areas where there is ongoing scientific and public concern.
From an administrative and funding standpoint, this opportunity is offered as a grant under the health funding activity category and is associated with CFDA number 93.161. The posting indicates an expected five awards, with an award ceiling of $500,000 per award. The opportunity was created on January 8, 2021, and the original application closing date was March 29, 2021, with electronic submissions due by 5:00 p.m. Eastern Time on the deadline. These details frame both the scale of support (moderate-sized research awards) and the competitive scope (a limited number of awards anticipated).
Eligibility is broad and includes many types of organizations that commonly conduct or support public health and biomedical research. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; and nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories). The listing also includes an "Others" category, with the implication that additional eligibility clarifications may exist in the full announcement text. Overall, the applicant pool is designed to allow participation by universities, public health agencies, and research-capable nonprofit entities, including those serving tribal communities.
In summary, this grant opportunity is designed to generate targeted, investigator-driven research that strengthens the evidence base on ALS risk factors and feeds into the National ALS Registry's mission to track ALS and understand who is affected and why. The preferred research areas signal a particular interest in service-related and exposure-related risks (such as military service and contact sports), injury-related mechanisms (traumatic brain injury), and biological mechanisms that could plausibly connect exposures to disease (neuroinflammation and infectious agents). The anticipated outcome is not just new academic knowledge, but actionable public health insight that improves surveillance, risk characterization, and the ability to identify contributing factors to ALS.Apply for RFA TS 21 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.161.
- This funding opportunity was created on Jan 08, 2021.
- Applicants must submit their applications by Mar 29, 2021 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
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